SCHEMBL6110012

SCHEMBL6110012

COc1cc(NC(=O)Nc2ccc(C(F)(F)F)cc2)ccc1C(=O)NCCN1CCCCC1

nearest known ligand 0.74

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 8/20 0.74
MCHR1 Q99705 10/20 0.67
MCHR2 Q969V1 2/20 0.65
HTR2A P28223 1/20 0.52
HTR2C P28335 1/20 0.52
HTR4 Q13639 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6109760 0.99 EPHX2 (0.75) EPHX2MCHR1MCHR2
SCHEMBL6108709 0.94 MCHR1 (0.76) EPHX2MCHR1MCHR2HTR4
SCHEMBL6108737 0.94 MCHR1 (0.74) EPHX2MCHR1MCHR2HTR4
SCHEMBL6110622 0.91 EPHX2 (0.77) EPHX2MCHR1
SCHEMBL6108942 0.90 MCHR1 (0.81) EPHX2MCHR1MCHR2
SCHEMBL6109144 0.89 MCHR1 (0.68) EPHX2MCHR1MCHR2HTR4
SCHEMBL6109301 0.88 MCHR1 (0.68) EPHX2MCHR1MCHR2HTR4
SCHEMBL6110881 0.87 MCHR1 (0.84) EPHX2MCHR1MCHR2HTR4
SCHEMBL6109200 0.87 MCHR1 (0.65) EPHX2MCHR1MCHR2
SCHEMBL6108746 0.87 MCHR1 (0.75) EPHX2MCHR1MCHR2HTR2AHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060235035-A1 Novel methoxybenzamibe compounds for use in mch receptor related disorders 7TM PHARMA A/S (DK) 2006-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060235035-A1 Novel methoxybenzamibe compounds for use in mch receptor related disorders GPR119, MCHR2, HCRTR2 EPHX2 2527/4885MCHR1 5/4885MCHR2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.