Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.74 |
| ▸ | HTR2C | P28335 | 3/20 | 0.74 |
| ▸ | DRD4 | P21917 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | HTR1D | P28221 | 1/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.74 |
| ▸ | HTR7 | P34969 | 1/20 | 0.74 |
| ▸ | HTR2B | P41595 | 1/20 | 0.74 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5274694 | 0.91 | HTR2A (0.73) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6109872 | 0.90 | HTR2A (0.69) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL6110794 | 0.89 | HTR2A (0.70) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| SCHEMBL5276777 | 0.86 | HTR2A (0.72) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Pruvanserin SCHEMBL9104227 | 0.85 | HTR2A (1.00) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Pruvanserin SCHEMBL29379046 | 0.85 | HTR2A (1.00) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Pruvanserin SCHEMBL678751 | 0.85 | HTR2A (1.00) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Hydrochloric Acid SCHEMBL27498823 | 0.85 | HTR2A (0.70) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Pruvanserin SCHEMBL678953 | 0.84 | HTR2A (0.98) | HTR2AHTR2CDRD4SLC6A2HTR1D | |
| Pruvanserin SCHEMBL29489913 | 0.84 | HTR2A (0.98) | HTR2AHTR2CDRD4SLC6A2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034788-A1 | COMBINATIONS OF N-(INDOLECARBONYL-)PIPERAZINE DERIVATIVES AND SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GMBH (DE) | 2006-04-06 | — | — | WO | disclosed |