Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111031 | 0.83 | EPHX2 (0.53) | EPHX2USP5LMNAMAPT | |
| SCHEMBL6110699 | 0.82 | TSHR (0.53) | EPHX2USP5LMNA | |
| SCHEMBL6110397 | 0.81 | EPHX2 (0.53) | EPHX2HCRTR1HCRTR2LMNAMMP1 | |
| SCHEMBL6111968 | 0.80 | EPHX2 (0.46) | EPHX2USP5 | |
| SCHEMBL15916020 | 0.80 | EPHX2 (0.51) | EPHX2MMP2MMP13 | |
| SCHEMBL6111072 | 0.77 | EPHX2 (0.48) | EPHX2HCRTR1HCRTR2LMNAMMP1 | |
| SCHEMBL2840532 | 0.74 | EPHX2 (0.45) | EPHX2HCRTR1HCRTR2LMNAMAPT | |
| SCHEMBL2834513 | 0.74 | EPHX2 (0.45) | EPHX2HCRTR1HCRTR2LMNAMAPT | |
| SCHEMBL19869964 | 0.73 | EPHX2 (0.47) | EPHX2HCRTR1HCRTR2LMNAMMP1 | |
| SCHEMBL2392198 | 0.73 | EPHX2 (0.41) | EPHX2LMNAMAPTMMP2MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006134481-A1 | INHIBITORS OF 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1 | PFIZER INC. (US) | 2006-12-21 | — | — | WO | disclosed |