Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 3/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5070782 | 0.84 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL6697715 | 0.80 | PSEN1 (0.66) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6701372 | 0.78 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL31070047 | 0.78 | KDM4E (0.62) | KDM4EALDH1A1CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL28433084 | 0.78 | KDM4E (0.62) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL29640958 | 0.76 | HRH3 (0.63) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL329891 | 0.76 | HRH3 (0.63) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL585363 | 0.76 | ALDH1A1 (0.60) | KDM4EALDH1A1CA12CA1CA2 | |
| SCHEMBL5069775 | 0.76 | MAOB (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5904129 | 0.76 | HRH3 (0.67) | KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138400-B2 | Sulfamides as gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2006-11-21 | — | — | US | disclosed |
| EP-1334085-B1 | SULFAMIDES AS GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME (GB) | 2005-08-24 | — | — | EP | disclosed |