Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.50 |
| ▸ | GRK5 | P34947 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6118164 | 0.94 | SCN5A (0.58) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL6118274 | 0.87 | SCN5A (0.54) | SCN5ALMNAMAPTTSHRALDH1A3 | |
| SCHEMBL11168443 | 0.87 | SCN5A (0.64) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL12575455 | 0.87 | SCN5A (0.51) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL16331235 | 0.86 | NT5E (0.57) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL6118675 | 0.84 | SCN5A (0.54) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL6118637 | 0.84 | SCN5A (0.54) | SCN5AKMT2ALMNAMAPTTSHR | |
| SCHEMBL6118604 | 0.83 | KDM4E (0.54) | SCN5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL6118554 | 0.83 | SCN5A (0.53) | SCN5AKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL6118923 | 0.83 | MAPK14 (0.59) | SCN5AKMT2ALMNAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199983-B2 | 3-aryl-6-aryl-[1,2,4]triazolo[4,3-α]pyridines as inhibitors of cell proliferation and the use thereof | CAI SUIXIONG (CN) | 2015-12-01 | — | — | US | disclosed |
| WO-2012065546-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012065297-A1 | 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF | IMPACT THERAPEUTICS, INC. (CN) | 2012-05-24 | — | — | WO | disclosed |