Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | WDR5 | P61964 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6118746 | 0.91 | CYP2C9 (0.54) | CYP2C9CYP3A4CYP2C19KCNH2 | |
| SCHEMBL6120172 | 0.90 | CYP2C9 (0.44) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL2295568 | 0.89 | CYP2C9 (0.48) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL6120327 | 0.88 | CYP2C9 (0.46) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL6119722 | 0.85 | CYP2C9 (0.45) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL4302637 | 0.85 | CYP2C9 (0.48) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL2302690 | 0.84 | CYP2C9 (0.45) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL22332678 | 0.83 | CYP2C9 (0.44) | CYP2C9CYP3A4CYP2C19KCNH2ANO1 | |
| SCHEMBL6119370 | 0.82 | MAPT (0.41) | CYP2C9CYP3A4CYP2C19KCNH2KDM4E | |
| SCHEMBL6119377 | 0.81 | CYP2C9 (0.49) | CYP2C9CYP3A4CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012067663-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2012-05-24 | — | — | WO | disclosed |