SCHEMBL2295568

SCHEMBL2295568

CS(=O)(=O)Nc1cc2oc(-c3ccc(F)cc3)c(C(=O)O)c2cc1C1CC1

nearest known ligand 0.48

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 5/20 0.48
CYP3A4 P08684 4/20 0.48
CYP2C19 P33261 4/20 0.48
KCNH2 Q12809 2/20 0.48
ANO1 Q5XXA6 9/20 0.42
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
WDR5 P61964 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6119722 0.95 CYP2C9 (0.45) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL2302690 0.94 CYP2C9 (0.45) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL2298467 0.91 CYP2C9 (0.47) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL2298808 0.90 CYP2C9 (0.59) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL6120327 0.90 CYP2C9 (0.46) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL2296799 0.90 CYP2C9 (0.43) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL6120266 0.89 CYP2C9 (0.41) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL6119280 0.89 TRPV1 (0.40) CYP2C9CYP3A4CYP2C19KCNH2ANO1
SCHEMBL6119844 0.89 CYP2C9 (0.50) CYP2C9CYP3A4CYP2C19KCNH2
SCHEMBL6120102 0.89 CYP2C9 (0.45) CYP2C9CYP3A4CYP2C19KCNH2ANO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107567442-B Inhibitors of hepatitis C virus polymerase 共晶制药公司 2021-05-25 CN disclosed
US-10947210-B2 Inhibitors of Hepatitis C virus polymerase COCRYSTAL PHARMA, INC. (US) 2021-03-16 US disclosed
US-20200255393-A1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE COCRYSTAL PHARMA, INC. 2020-08-13 US disclosed
US-10464914-B2 Inhibitors of hepatitis C virus polymerase COCRYSTAL PHARMA, INC. (US) 2019-11-05 US disclosed
EP-3274340-B1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE COCRYSTAL PHARMA INC (US) 2019-07-17 EP disclosed
EP-2744342-B1 THERAPEUTIC METHODS GLAXOSMITHKLINE LLC (US) 2019-04-24 EP disclosed
US-10238678-B2 Therapeutic methods GLAXOSMITHKLINE LLC (US) 2019-03-26 US disclosed
US-20180050998-A1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE COCRYSTAL PHARMA, INC. 2018-02-22 US disclosed
EP-3274340-A1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE Cocrystal Pharma, Inc. (US) 2018-01-31 EP disclosed
EP-3199531-A1 BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS Glaxo Group Limited (GB) 2017-08-02 EP disclosed
US-7666863-B2 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases VIROPHARMA INCORPORATED (US) 2010-02-23 US disclosed
US-20090281336-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES SAHA ASHIS K 2009-11-12 US disclosed
US-20080075695-A1 COMBINATION THERAPY METHOD FOR TREATING HEPATITIS C VIRUS INFECTION AND PHARMACEUTICAL COMPOSITIONS FOR USE THEREIN HOWE ANITA Y 2008-03-27 US disclosed
WO-2008024843-A2 COMBINATION THERAPY METHOD FOR TREATING HEPATITIS C VIRUS INFECTION AND PHARMACEUTICAL COMPOSITIONS FOR USE THEREIN VIROPHARMA INCORPORATED (US) 2008-02-28 WO disclosed
US-20070231318-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES SAHA ASHIS K 2007-10-04 US disclosed
US-7265152-B2 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases VIROPHARMA INCORPORATED (US) 2007-09-04 US disclosed
EP-1581207-A4 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INC (US) 2007-07-25 EP disclosed
EP-1581207-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES Viropharma Incorporated (US) 2005-10-05 EP disclosed
US-20040162318-A1 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases VIROPHARMA INCORPORATED 2004-08-19 US disclosed
WO-2004041201-A2 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES VIROPHARMA INCORPORATED (US) 2004-05-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070231318-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES BBOX1, HAVCR2, CYP2E1 CYP2C9 129/4885CYP3A4 38/4885CYP2C19 117/4885
US-20200255393-A1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE POLI, POLR2E, POLR2H CYP2C9 633/4885CYP3A4 437/4885CYP2C19 786/4885
US-10464914-B2 Inhibitors of hepatitis C virus polymerase POLI, POLR2E, POLR2H CYP2C9 633/4885CYP3A4 437/4885CYP2C19 786/4885
US-10238678-B2 Therapeutic methods HAVCR2, SLC10A1, OAT CYP2C9 2142/4885CYP3A4 1989/4885CYP2C19 2218/4885
US-20090281336-A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES BBOX1, HAVCR2, CYP2E1 CYP2C9 129/4885CYP3A4 38/4885CYP2C19 117/4885
US-10947210-B2 Inhibitors of Hepatitis C virus polymerase POLI, POLR2E, POLR2H CYP2C9 633/4885CYP3A4 437/4885CYP2C19 786/4885
US-20040162318-A1 Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases BBOX1, HAVCR2, CYP2E1 CYP2C9 129/4885CYP3A4 38/4885CYP2C19 117/4885
US-20180050998-A1 INHIBITORS OF HEPATITIS C VIRUS POLYMERASE POLI, POLR2E, POLR2H CYP2C9 633/4885CYP3A4 437/4885CYP2C19 786/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.