Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8102249 | 0.88 | GAA (0.67) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL5336971 | 0.85 | POLB (0.59) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL11884577 | 0.84 | GAA (0.63) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL11454486 | 0.84 | L3MBTL1 (0.47) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL11446908 | 0.84 | L3MBTL1 (0.47) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL1519333 | 0.84 | CYP4F2 (0.50) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL1519271 | 0.84 | CYP4F2 (0.50) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL11465271 | 0.83 | CYP4F2 (0.49) | TSHRGAAL3MBTL1NPSR1LMNA | |
| SCHEMBL30606872 | 0.82 | NPC1 (0.62) | TSHRGAAL3MBTL1NPSR1NPC1 | |
| SCHEMBL30606873 | 0.82 | NPC1 (0.62) | TSHRGAAL3MBTL1NPSR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064408-A1 | “PROCESS FOR THE PREPARATION OF ETHYL 2, 3-DIHYDROBENZO[1,4]DIOXIN-2-CARBOXYLATE” | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-08-07 | — | — | WO | claimed |
| US-6555695-B1 | Reacting catechol with a base in a hydrocarbon solvent; refluxing to dehydrate; adding polyethylene glycol as a phase transfer catalyst, 2,3-dibromopropionate, and an antifoam agent; intermediate for hypotensive agent, Doxazoxin | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2003-04-29 | — | — | US | claimed |
| WO-2023146244-A1 | BENZODIOXANE DERIVATIVE COMPOUNDS AND MEDICAL USE THEREOF | 재단법인 한국파스퇴르연구소 | 2023-08-03 | — | — | WO | disclosed |
| EP-2421857-B1 | PROCESS FOR THE PREPARATION OF DOXAZOSIN AND SALTS THEREOF | CIPLA LTD (IN) | 2013-08-28 | — | — | EP | disclosed |
| EP-2421857-B1 | PROCESS FOR THE PREPARATION OF DOXAZOSIN AND SALTS THEREOF | CIPLA LTD (IN) | 2013-08-28 | — | — | EP | disclosed |
| CN-102127052-B | Method for synthesizing 1,4-benzdioxan-2-carboxylic acid | UNIV ZHEJIANG | 2013-05-01 | — | — | CN | disclosed |
| CN-102127052-B | Method for synthesizing 1,4-benzdioxan-2-carboxylic acid | UNIV ZHEJIANG | 2013-05-01 | — | — | CN | disclosed |
| US-8426590-B2 | Process for the preparation of doxazosin and salts thereof | CIPLA LIMITED (IN) | 2013-04-23 | — | — | US | disclosed |
| US-8426590-B2 | Process for the preparation of doxazosin and salts thereof | CIPLA LIMITED (IN) | 2013-04-23 | — | — | US | disclosed |
| US-8426590-B2 | Process for the preparation of doxazosin and salts thereof | CIPLA LIMITED (IN) | 2013-04-23 | — | — | US | disclosed |
| EP-2421857-A2 | Process for the preparation of doxazosin and salts thereof | CIPLA LIMITED (IN) | 2012-02-29 | — | — | EP | disclosed |
| US-6313160-B1 | FOR THERAPY AND PROPHYLAXIS OF MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-06 | — | — | US | disclosed |
| EP-0833937-A1 | OPTICAL RESOLUTION OF ALKYL 1,4-BENZODIOXAN-2-CARBOXYLATES USING ESTERASE FROM SERRATIA MARCESCENS | Seprachem, Inc. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040976-A1 | OPTICAL RESOLUTION OF ALKYL 1,4-BENZODIOXAN-2-CARBOXYLATES USING ESTERASE FROM SERRATIA MARCESCENS | SEPRACHEM, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5529929-A | USING AQUEOUS SOLUTION OF MICROBIAL ESTERASE | SEPRACHEM, INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5439909-A | 2-Substituted with amide or thioamide group; antioxidant for lipoproteins, antilipemic agents, anticholesterol agents | ADIR ET COMPAGNIE (FR) | 1995-08-08 | — | — | US | disclosed |
| US-5420132-A | Antilipemic agents | ADIR ET COMPAGNIE (FR) | 1995-05-30 | — | — | US | disclosed |
| WO-1981003172-A1 | NOVEL BENZO(1,4)DIOXINS,METHODS FOR THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS | CERM CENT EUROP RECH MAUVERNAY (FR) | 1981-11-12 | — | — | WO | disclosed |
| US-4208424-A | Lipogenesis inhibition by certain esters of substituted benzodioxincarboxylic acids | SHELL OIL COMPANY (US) | 1980-06-17 | — | — | US | disclosed |
| US-4118507-A | Benzodioxincarboxamide lipogenesis inhibitors | SHELL OIL COMPANY (US) | 1978-10-03 | — | — | US | disclosed |