Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982068 | 1.00 | POLB (0.62) | POLBNR3C2MAPTALDH1A1LMNA | |
| SCHEMBL1984022 | 1.00 | POLB (0.62) | POLBNR3C2MAPTALDH1A1LMNA | |
| SCHEMBL1981826 | 0.93 | POLB (0.55) | POLBNR3C2MAPTALDH1A1LMNA | |
| SCHEMBL12977895 | 0.91 | POLB (0.52) | POLBNR3C2MAPTALDH1A1LMNA | |
| SCHEMBL1987813 | 0.85 | MEN1 (0.46) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL1982952 | 0.85 | MAPT (0.47) | POLBMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1982611 | 0.85 | POLB (0.46) | POLBNR3C2MAPTALDH1A1LMNA | |
| SCHEMBL1984298 | 0.84 | ALDH1A1 (0.51) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL1984816 | 0.83 | ALDH1A1 (0.50) | POLBMAPTALDH1A1LMNAMAPK1 | |
| SCHEMBL13570058 | 0.82 | POLB (0.58) | POLBNR3C2MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2455376-A1 | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |