SCHEMBL6124751

SCHEMBL6124751

CC(C)(C)[Si](C)(C)OCC(N)c1ccc(F)cc1

nearest known ligand 0.35

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 3/20 0.35
TDO2 P48775 2/20 0.35
SCN4A P35499 5/20 0.34
AOC3 Q16853 2/20 0.34
BCDIN3D Q7Z5W3 2/20 0.33
DPP4 P27487 2/20 0.32
TACR1 P25103 1/20 0.32
ADRB2 P07550 1/20 0.32
ADRB1 P08588 1/20 0.32
ADRB3 P13945 1/20 0.32
DPP8 Q6V1X1 1/20 0.32
AGXT P21549 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23215033 1.00 IDO1 (0.35) IDO1TDO2SCN4AAOC3BCDIN3D
SCHEMBL31739155 0.84 TACR1 (0.42) IDO1TACR1
SCHEMBL16761917 0.84 SCN4A (0.32) IDO1SCN4ATACR1
SCHEMBL16793913 0.84 DPP4 (0.35) IDO1SCN4ADPP4TACR1
SCHEMBL1850702 0.83 SCN4A (0.49) SCN4ATACR1
SCHEMBL22502109 0.83 SCN4A (0.49) SCN4ATACR1
SCHEMBL366662 0.83 SCN4A (0.49) SCN4ATACR1
SCHEMBL31739159 0.83 CYP1A2 (0.50) IDO1AOC3TACR1AGXT
SCHEMBL1516258 0.82 DPP4 (0.37) SCN4ABCDIN3DDPP4TACR1ADRB2
SCHEMBL2524000 0.81 GABBR2 (0.42) IDO1TDO2AOC3ADRB2ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260138987-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CONTINEUM THERAPEUTICS INC (US) 2026-05-21 US disclosed
US-12565501-B2 Muscarinic acetylcholine M1 receptor antagonists CONTINEUM THERAPEUTICS, INC. (US) 2026-03-03 US disclosed
US-20250171455-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CONTINEUM THERAPEUTICS INC (US) 2025-05-29 US disclosed
US-20230089921-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CONTINEUM THERAPEUTICS, INC. 2023-03-23 US disclosed
CN-114729044-A Muscarinic acetylcholine M1Receptor antagonists 帕珀莱恩医疗公司 2022-07-08 CN disclosed
WO-2021071843-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS Pipeline Therapeutics, Inc. (US) 2021-04-15 WO disclosed
US-8487099-B2 Gamma secretase modulators MERCK SHARP & DOHME CORP. (US) 2013-07-16 US disclosed
US-8487099-B2 Gamma secretase modulators MERCK SHARP & DOHME CORP. (US) 2013-07-16 US disclosed
US-20120107328-A1 GAMMA SECRETASE MODULATORS MERCK SHARP & DOHME CORP. 2012-05-03 US disclosed
US-20100256128-A1 GAMMA SECRETASE MODULATORS SCHERING CORPORATION (US) 2010-10-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120107328-A1 GAMMA SECRETASE MODULATORS BACE1, BACE2, PSEN1 IDO1 4504/4885TDO2 4780/4885SCN4A 1045/4885
US-20100256128-A1 GAMMA SECRETASE MODULATORS BACE1, BACE2, PSEN1 IDO1 4402/4885TDO2 4797/4885SCN4A 672/4885
US-12565501-B2 Muscarinic acetylcholine M1 receptor antagonists CHRM1, CHRM2, CHRM3 IDO1 764/4885TDO2 2155/4885SCN4A 506/4885
US-20230089921-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CHRM1, CHRM2, CHRM3 IDO1 613/4885TDO2 3046/4885SCN4A 1000/4885
US-20260138987-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CHRM1, CHRM5, CHRM3 IDO1 785/4885TDO2 2000/4885SCN4A 360/4885
US-20250171455-A1 MUSCARINIC ACETYLCHOLINE M1 RECEPTOR ANTAGONISTS CHRM1, CHRM2, CHRM3 IDO1 604/4885TDO2 3048/4885SCN4A 1006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.