Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 7/20 | 0.32 |
| ▸ | CDC7 | O00311 | 5/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 5/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 5/20 | 0.32 |
| ▸ | PAK4 | O96013 | 5/20 | 0.32 |
| ▸ | PIM1 | P11309 | 5/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6127376 | 1.00 | PRCP (0.35) | PRCPRAB9AS1PR2USP30HCAR3 | |
| SCHEMBL952528 | 0.86 | CDC7 (0.42) | CCNT1PDGFRBPDGFRACDK9CDC7 | |
| SCHEMBL951702 | 0.83 | MEN1 (0.43) | RAB9APDGFRBPDGFRACDC7DAPK3 | |
| SCHEMBL1044830 | 0.83 | USP30 (0.32) | USP30 | |
| SCHEMBL1044831 | 0.83 | USP30 (0.32) | USP30 | |
| SCHEMBL1045105 | 0.81 | PRMT5 (0.40) | USP30CDK9CDC7DAPK3ROCK2 | |
| SCHEMBL1045103 | 0.81 | PRMT5 (0.40) | USP30CDK9CDC7DAPK3ROCK2 | |
| Cyclohexylamine SCHEMBL1043815 | 0.79 | NUDT1 (0.40) | CCNT1PDGFRBPDGFRACDK9CDC7 | |
| SCHEMBL1045104 | 0.75 | USP30 (0.35) | USP30 | |
| SCHEMBL992715 | 0.74 | PRCP (0.38) | PRCPRAB9AS1PR2HCAR3PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2454257-B1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | ABBVIE INC (US) | 2013-08-21 | — | — | EP | disclosed |
| EP-2454257-A1 | PYRROLOPYRIDINE INHIBITORS OF KINASES | Abbott Laboratories (US) | 2012-05-23 | — | — | EP | disclosed |