Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MMP3 | P08254 | 3/20 | 0.45 |
| ▸ | EPOR | P19235 | 1/20 | 0.44 |
| ▸ | MMP7 | P09237 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6129751 | 1.00 | ATM (0.53) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL56847 | 0.81 | EPOR (0.52) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL55668 | 0.81 | EPOR (0.52) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL55669 | 0.81 | EPOR (0.52) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL28784090 | 0.80 | MMP1 (0.50) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL28784089 | 0.80 | MMP1 (0.50) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL24391645 | 0.75 | TSHR (0.66) | CA2MMP2MMP9MMP8CA1 | |
| SCHEMBL7360135 | 0.75 | MMP1 (0.73) | ATMMMP1CA2MMP2MMP9 | |
| SCHEMBL5139178 | 0.75 | ATM (0.54) | ATMMMP1MMP9MMP13NPSR1 | |
| SCHEMBL5139176 | 0.75 | ATM (0.54) | ATMMMP1MMP9MMP13NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282694-A4 | SULFAMIDE AND BIS-SULFAMIDE AMINO ACID DERIVATIVES AS INHIBITORS OF PROTEOLYTIC ENZYMES | SUPERGEN INC (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1282694-A1 | SULFAMIDE AND BIS-SULFAMIDE AMINO ACID DERIVATIVES AS INHIBITORS OF PROTEOLYTIC ENZYMES | Supergen, Inc. (US) | 2003-02-12 | — | — | EP | disclosed |
| US-6495358-B1 | OPEN SULFAMIDE STRUCTURE IS ANTICIPATED TO BE MORE STABLE CHEMICALLY THAN RELATED CLOSED RING STRUCTURES; SERINE AND CYSTEINE PROTEASES | WICHITA STATE UNIVERSITY | 2002-12-17 | — | — | US | disclosed |
| WO-2001081561-A1 | SULFAMIDE AND BIS-SULFAMIDE AMINO ACID DERIVATIVES AS INHIBITORS OF PROTEOLYTIC ENZYMES | SUPERGEN, INC. (US) | 2001-11-01 | — | — | WO | disclosed |