SCHEMBL6130286

SCHEMBL6130286

O=C(O)Nc1ccccc1CON1C(=O)c2ccccc2C1=O

nearest known ligand 0.54

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
HTT P42858 1/20 0.52
CYP1A2 P05177 2/20 0.49
CYP2C9 P11712 1/20 0.49
GAA P10253 1/20 0.47
MEN1 O00255 6/20 0.46
KMT2A Q03164 6/20 0.46
MAPT P10636 1/20 0.46
GRM5 P41594 1/20 0.42
ATM Q13315 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21045881 0.82 ALDH1A1 (0.46) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL27578681 0.78 GRM5 (0.65) MEN1KMT2AGRM5
SCHEMBL11001273 0.74 ALDH1A1 (0.52) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL27647896 0.73 IDO1 (0.48) ALDH1A1GAAMAPT
SCHEMBL9407121 0.73 TP53 (0.46) ALDH1A1HTTGAAKMT2AMAPT
SCHEMBL8914413 0.72 KMT2A (0.61) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL17161188 0.72 ALDH1A1 (0.60) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL21045989 0.72 MEN1 (0.61) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL3374656 0.72 ALDH1A1 (0.60) ALDH1A1HTTCYP1A2CYP2C9GAA
SCHEMBL12381662 0.71 ALDH1A1 (0.52) ALDH1A1HTTCYP1A2CYP2C9GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1347952-A4 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2005-10-26 EP disclosed
EP-1347952-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES Dow AgroSciences LLC (US) 2003-10-01 EP disclosed
WO-2002046142-A1 ARYL AND HETEROARYLCYCLOPROPYL OXIME ETHERS AND THEIR USE AS FUNGICIDES DOW AGROSCIENCES LLC (US) 2002-06-13 WO disclosed