Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 17/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8236120 | 0.77 | HDAC1 (0.48) | HDAC1HDAC2HDAC6 | |
| SCHEMBL1065409 | 0.76 | HDAC1 (0.58) | ARHDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL1065410 | 0.76 | HDAC1 (0.53) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL8279067 | 0.75 | HDAC1 (0.71) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL2733350 | 0.75 | HDAC1 (0.80) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL4064130 | 0.75 | MEN1 (1.00) | MEN1LMNAKMT2AAR | |
| SCHEMBL8401704 | 0.74 | HDAC1 (0.89) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL4715033 | 0.73 | HDAC1 (0.70) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL211677 | 0.73 | HDAC1 (0.76) | HDAC1HDAC2HDAC3NCOR2HDAC6 | |
| SCHEMBL211107 | 0.73 | HDAC1 (0.70) | HDAC1HDAC2HDAC3NCOR2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897220-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2005-05-24 | — | — | US | disclosed |