Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | HTR7 | P34969 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 4/20 | 0.62 |
| ▸ | DRD4 | P21917 | 4/20 | 0.62 |
| ▸ | DRD3 | P35462 | 4/20 | 0.62 |
| ▸ | HRH1 | P35367 | 3/20 | 0.62 |
| ▸ | HRH2 | P25021 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6132013 | 0.89 | KDM4E (0.63) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131833 | 0.86 | KDM4E (0.71) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131822 | 0.86 | KDM4E (0.74) | KDM4EMAPTHTR7LMNAHTT | |
| Hydrochloric Acid SCHEMBL7689058 | 0.84 | KDM4E (0.71) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131816 | 0.84 | KDM4E (0.68) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL9720681 | 0.82 | MAPK1 (0.78) | KDM4EHTR7LMNAHTTTDP1 | |
| SCHEMBL9720709 | 0.80 | KDM4E (0.71) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131927 | 0.80 | KDM4E (0.65) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131856 | 0.80 | KDM4E (0.67) | KDM4EMAPTHTR7LMNAHTT | |
| SCHEMBL6131901 | 0.80 | KDM4E (0.62) | KDM4EMAPTHTR7LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6479495-B1 | SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |