Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21119060 | 0.87 | CA12 (0.53) | HPGDSMN1; SMN2TP53MAPK1RAB9A | |
| SCHEMBL12187774 | 0.84 | ALDH1A1 (0.52) | HPGDSMN1; SMN2TP53MAPK1ALDH1A1 | |
| SCHEMBL22420308 | 0.80 | ALDH1A1 (0.71) | HPGDSMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL4568727 | 0.80 | HPGD (0.63) | HPGDSMN1; SMN2NPC1TSHRTP53 | |
| SCHEMBL9681207 | 0.79 | ALDH1A1 (0.52) | HPGDSMN1; SMN2TSHRTP53MAPK1 | |
| SCHEMBL31331632 | 0.79 | KMT2A (0.62) | HPGDSMN1; SMN2NPC1TSHRRAB9A | |
| SCHEMBL11816602 | 0.79 | ALDH1A1 (0.67) | HPGDSMN1; SMN2NPC1TSHRTP53 | |
| SCHEMBL31331759 | 0.78 | MAPT (0.62) | HPGDSMN1; SMN2NPC1TP53RAB9A | |
| SCHEMBL11471717 | 0.77 | SMN1; SMN2 (1.00) | HPGDSMN1; SMN2NPC1TSHRTP53 | |
| SCHEMBL10262718 | 0.77 | MAPT (0.52) | HPGDSMN1; SMN2NPC1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214310-B1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1214310-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-6348604-B1 | COMPOUNDS IN WHICH SELECTION AND PLACEMENT OF SUBSTITUENTS CONTROL WAVELENGTH AND/OR INTENSITY OF VISIBLE ABSORBANCE BANDS | PPG INDUSTRIES OHIO, INC. | 2002-02-19 | — | — | US | disclosed |
| WO-2001019812-A1 | NOVEL PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2001-03-22 | — | — | WO | disclosed |