Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571573 | 0.80 | CYP3A4 (0.59) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL11690706 | 0.78 | OPRL1 (0.51) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL28447051 | 0.76 | GAA (0.56) | CYP2D6TSHRCYP3A4KMT2APOLB | |
| SCHEMBL11686069 | 0.76 | OPRL1 (0.52) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL9177696 | 0.75 | OPRL1 (0.51) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL7511281 | 0.74 | OPRL1 (0.57) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL11683058 | 0.74 | OPRL1 (0.50) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| Hydrochloric Acid SCHEMBL6543173 | 0.73 | POLB (0.58) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 | |
| SCHEMBL4502776 | 0.73 | POLB (0.52) | CYP2D6TSHRCYP3A4ALDH1A1KMT2A | |
| SCHEMBL12406526 | 0.73 | CYP3A4 (0.50) | CYP2D6TSHRCYP3A4ALDH1A1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| US-6479495-B1 | SIMULTANEOUSLY TREATING DEPRESSION AND MEMORY DYSFUNCTION IN MAMMALS SUFFERING FROM MEMORY DYSFUNCTION AND DEPRESSION | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |