Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 10/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
| ▸ | LIPC | P11150 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133632 | 0.97 | HDAC3 (0.48) | HDAC3HDAC8GRM2ALDH1A1MAPT | |
| SCHEMBL6132700 | 0.92 | ALDH1A1 (0.46) | HDAC3HDAC8GRM2ALDH1A1MAPT | |
| SCHEMBL6132706 | 0.92 | ALDH1A1 (0.46) | HDAC3HDAC8GRM2ALDH1A1MAPT | |
| SCHEMBL6134902 | 0.88 | ALDH1A1 (0.50) | GRM2ALDH1A1MAPTHPGDTSHR | |
| SCHEMBL6135350 | 0.87 | HDAC3 (0.47) | HDAC3HDAC8GRM2ALDH1A1MAPT | |
| SCHEMBL6134206 | 0.86 | HDAC3 (0.47) | HDAC3HDAC8ALDH1A1MAPTHPGD | |
| SCHEMBL6134511 | 0.84 | ALDH1A1 (0.47) | ALDH1A1MAPTHPGDTSHRNPC1 | |
| SCHEMBL6135356 | 0.84 | CSNK2A2 (0.44) | HDAC3HDAC8GRM2ALDH1A1MAPT | |
| SCHEMBL6134785 | 0.83 | MAPT (0.50) | HDAC3HDAC8ALDH1A1MAPTHPGD | |
| SCHEMBL6132214 | 0.83 | MEN1 (0.43) | HDAC3HDAC8ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | HDAC3 1145/4885HDAC8 2744/4885GRM2 2621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.