Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6134521 | 0.89 | MKNK1 (0.45) | MKNK1MKNK2FFAR4FFAR1EPHX2 | |
| SCHEMBL6134929 | 0.85 | MKNK1 (0.47) | MKNK1MKNK2ALDH1A1 | |
| SCHEMBL6135144 | 0.85 | MKNK1 (0.47) | MKNK1MKNK2 | |
| SCHEMBL6134597 | 0.85 | MKNK1 (0.48) | MKNK1MKNK2RARARARBRARG | |
| SCHEMBL6134954 | 0.83 | MKNK1 (0.47) | MKNK1MKNK2MAPTALDH1A1TSHR | |
| SCHEMBL6135134 | 0.83 | TP53 (0.44) | CCNCCDK8RARARARBRARG | |
| SCHEMBL6135447 | 0.82 | ALDH1A1 (0.55) | CCNCCDK8MAPTALDH1A1TSHR | |
| SCHEMBL6135026 | 0.80 | MKNK1 (0.47) | MKNK1MKNK2 | |
| SCHEMBL6134291 | 0.80 | MKNK1 (0.43) | MKNK1MKNK2MAPTFFAR1EPHX2 | |
| SCHEMBL6134883 | 0.79 | HDAC3 (0.51) | MKNK1MKNK2MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261177-A1 | Compound | ASTELLAS PHARMA INC. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261177-A1 | Compound | MANBA, MAN2B1, MAN2A1 | MKNK1 2695/4885MKNK2 3220/4885CCNC 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.