⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11997982 | 1.00 | — | — | |
| SCHEMBL18980132 | 1.00 | — | — | |
| SCHEMBL12301657 | 0.82 | KCNH2 (0.31) | — | |
| SCHEMBL14300995 | 0.82 | KCNH2 (0.31) | — | |
| SCHEMBL18909422 | 0.80 | HTR2A (0.37) | — | |
| SCHEMBL19488728 | 0.80 | HTR2A (0.37) | — | |
| SCHEMBL11878714 | 0.80 | HTR2A (0.37) | — | |
| SCHEMBL7766013 | 0.79 | — | — | |
| SCHEMBL14577480 | 0.77 | CA1 (0.39) | — | |
| SCHEMBL27702123 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539128-A2 | USE OF SKIN-PROTECTING SUBSTANCES | Phenion GmbH & Co KG (DE) | 2005-06-15 | — | — | EP | claimed |
| WO-2004026295-A9 | USE OF SKIN-PROTECTING SUBSTANCES | PHENION GMBH & CO KG (DE) | 2004-09-16 | — | — | WO | claimed |
| WO-2004026295-A2 | USE OF SKIN-PROTECTING SUBSTANCES | PHENION GMBH & CO. KG (DE) | 2004-04-01 | — | — | WO | claimed |
| US-20250059157-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2025-02-20 | — | — | US | disclosed |
| US-20230303514-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2023-09-28 | — | — | US | disclosed |
| CN-112574061-B | TRPV1 agonist and preparation method and application thereof | 南京清普生物科技有限公司 | 2023-05-19 | — | — | CN | disclosed |
| US-11629134-B2 | TLR7/8 antagonists and uses thereof | MERCK PATENT GMBH (DE) | 2023-04-18 | — | — | US | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| CN-115103907-A | Compositions and methods for enhancing immune activity | 金橘生物科技公司 | 2022-09-23 | — | — | CN | disclosed |
| CN-108699032-B | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2022-07-22 | — | — | CN | disclosed |
| CN-113603675-A | Polycyclic TLR7/8 antagonists and their use in the treatment of immune disorders | 默克专利有限公司 | 2021-11-05 | — | — | CN | disclosed |
| WO-2017106607-A1 | POLYCYCLIC TLR7/8 ANTAGONISTS AND USE THEREOF IN THE TREATMENT OF IMMUNE DISORDERS | MERCK PATENT GMBH (DE) | 2017-06-22 | — | — | WO | disclosed |
| WO-2016081522-A1 | NANOMATERIAL COMPOSITIONS, SYNTHESIS, AND ASSEMBLY | RHODE ISLAND HOSPITAL (US) | 2016-05-26 | — | — | WO | disclosed |
| US-20110059940-A1 | 2-Aryl Glycinamide Derivatives | BRISTOL- MYERS SQUIBB COMPANY | 2011-03-10 | — | — | US | disclosed |
| EP-1423382-B1 | PYRAZOLE-DERIVED KINASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1539128-A2 | USE OF SKIN-PROTECTING SUBSTANCES | Phenion GmbH & Co KG (DE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004026295-A9 | USE OF SKIN-PROTECTING SUBSTANCES | PHENION GMBH & CO KG (DE) | 2004-09-16 | — | — | WO | disclosed |
| WO-2004026295-A2 | USE OF SKIN-PROTECTING SUBSTANCES | PHENION GMBH & CO. KG (DE) | 2004-04-01 | — | — | WO | disclosed |
| EP-0877018-B1 | Sulfonylaminocarboxylic acids | AVENTIS PHARMA GMBH (DE) | 2003-05-02 | — | — | EP | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |