Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM5C | P41229 | 2/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41068 | 0.89 | — | — | |
| SCHEMBL3882468 | 0.87 | FFAR3 (0.43) | OR51E2FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL31198194 | 0.87 | — | — | |
| SCHEMBL27503883 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL272523 | 0.87 | — | — | |
| Hydrochloric Acid SCHEMBL23174893 | 0.87 | — | — | |
| Diethylamine SCHEMBL8088673 | 0.87 | GLRA1 (0.59) | GLRA1SLC6A9OR51E2GABRR1FFAR3 | |
| Ammonia Solution, Strong SCHEMBL1361604 | 0.87 | — | — | |
| SCHEMBL28851694 | 0.87 | — | — | |
| SCHEMBL27740772 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110669105-B | Long-acting polypeptide construction and application thereof in resisting acute kidney injury and diabetic complication nephropathy | 华中科技大学 | 2021-06-11 | — | — | CN | disclosed |
| CN-110669105-A | Long-acting polypeptide construction and application thereof in resisting acute kidney injury and diabetic complication nephropathy | 华中科技大学 | 2020-01-10 | — | — | CN | disclosed |
| EP-1539128-A2 | USE OF SKIN-PROTECTING SUBSTANCES | Phenion GmbH & Co KG (DE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004026295-A2 | USE OF SKIN-PROTECTING SUBSTANCES | PHENION GMBH & CO. KG (DE) | 2004-04-01 | — | — | WO | disclosed |