Toluene Diisocyanate

Toluene Diisocyanate

SCHEMBL6135590

Cc1ccc(N=C=O)cc1N=C=O.c1ccc(Cc2ccccc2)cc1

nearest known ligand 0.73

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.73
TRPA1 O75762 1/20 0.73
TSHR P16473 2/20 0.51
CYP1A2 P05177 1/20 0.43
MAPK1 P28482 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
CALM1 P0DP23 1/20 0.36
SLC22A2 O15244 1/20 0.36
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 1/20 0.35
CYP2C9 P11712 1/20 0.33
LMNA P02545 1/20 0.33
NQO1 P15559 1/20 0.33
LDHA P00338 1/20 0.33
LDHB P07195 1/20 0.33
MEN1 O00255 1/20 0.33
NPC1 O15118 1/20 0.33
USP2 O75604 1/20 0.33
MAPT P10636 1/20 0.33
RAB9A P51151 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene Diisocyanate SCHEMBL3468300 0.96 CYP3A4 (0.67) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL28776046 0.96 CYP3A4 (0.67) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL11217721 0.91 CYP3A4 (0.77) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL2054278 0.87 CYP3A4 (0.83) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL637112 0.86 CYP3A4 (0.80) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL27995911 0.85 CYP3A4 (0.86) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL29737260 0.85 CYP3A4 (1.00) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL15384 0.85 CYP3A4 (1.00) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL29350148 0.85 CYP3A4 (1.00) CYP3A4TRPA1TSHRCYP1A2MAPK1
Toluene Diisocyanate SCHEMBL28174227 0.85 CYP3A4 (1.00) CYP3A4TRPA1TSHRCYP1A2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017067979-A1 RED OIL-BASED INKJET INK COMPRISING IRON OXIDE PIGMENTS INNOVACIONES TÉCNICAS APLICADAS A CERÁMICAS AVANZADAS, S.A.U. (ES) 2017-04-27 WO disclosed
US-20050191485-A1 Film and adhesive therefor BRIDGESTONE CORPORATION 2005-09-01 US disclosed
EP-1564239-A1 FILM AND PRESSURE-SENSITIVE ADHESIVE FOR USE THEREIN Bridgestone Corporation (JP) 2005-08-17 EP disclosed