Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.50 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5887805 | 0.82 | ADAM17 (0.51) | ADAM17MMP13MMP2MMP3MMP7 | |
| Trifluoroacetic Acid SCHEMBL5887636 | 0.77 | ADAM17 (0.48) | ADAM17MMP13 | |
| SCHEMBL5887640 | 0.73 | ADAM17 (0.46) | ADAM17MMP13MMP2 | |
| SCHEMBL3882588 | 0.72 | ADAM17 (0.65) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL2682726 | 0.72 | ADAM17 (0.65) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL2681099 | 0.71 | ADAM17 (0.67) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL6100721 | 0.71 | ADAM17 (0.64) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL6100731 | 0.71 | ADAM17 (0.67) | ADAM17MMP13MMP2MMP3MMP7 | |
| Hydrochloric Acid SCHEMBL2682656 | 0.71 | ADAM17 (0.64) | ADAM17MMP13MMP2MMP3MMP7 | |
| SCHEMBL6100716 | 0.71 | ADAM17 (0.66) | ADAM17MMP13MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546109-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2005-11-09 | — | — | EP | claimed |
| EP-1546109-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2005-06-29 | — | — | EP | claimed |
| WO-2004033632-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-22 | — | — | WO | claimed |