Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136136 | 0.83 | TRPV1 (0.50) | EPHX1KDM4ETRPV1HDAC1ROCK2 | |
| SCHEMBL6136254 | 0.81 | TRPV1 (0.47) | TRPV1ROCK2MEN1KMT2AHTT | |
| SCHEMBL6136126 | 0.79 | TRPV1 (0.47) | EPHX1TRPV1HDAC1ROCK2SMN1; SMN2 | |
| SCHEMBL6136184 | 0.75 | CNR1 (0.54) | TRPV1MEN1KMT2AHTTLMNA | |
| SCHEMBL6136378 | 0.75 | MTOR (0.48) | TRPV1HDAC1HDAC6ROCK2 | |
| SCHEMBL6136033 | 0.73 | CNR1 (0.49) | TRPV1ROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL6136240 | 0.71 | NPC1 (0.53) | MEN1KMT2ATP53SMN1; SMN2CYP3A4 | |
| SCHEMBL6136280 | 0.71 | ERCC1 (0.49) | TRPV1MEN1KMT2ACNR1 | |
| SCHEMBL6136147 | 0.70 | MTOR (0.61) | TRPV1TP53 | |
| SCHEMBL9418189 | 0.70 | TRPV1 (0.50) | KDM4ETRPV1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0895989-B1 | 1-[4-(Substituted alkoxy)benzyl] naphthalene compounds having estrogen inhibitory activity | LILLY CO ELI (US) | 2005-05-18 | — | — | EP | claimed |