⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vuf-5296 SCHEMBL7784076 | 1.00 | — | — | |
| Vuf-5297 SCHEMBL7508989 | 1.00 | — | — | |
| Vuf-5296 SCHEMBL8846403 | 1.00 | — | — | |
| Vuf-5296 SCHEMBL8846552 | 1.00 | — | — | |
| SCHEMBL2895063 | 0.80 | — | — | |
| SCHEMBL6136828 | 0.76 | HRH3 (0.46) | — | |
| SCHEMBL2262101 | 0.76 | HRH3 (0.46) | — | |
| SCHEMBL8846230 | 0.75 | — | — | |
| SCHEMBL8846549 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL6782159 | 0.75 | HRH3 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841923-B1 | 1H-4(5)-SUBSTITUTED IMIDAZOLE DERIVATIVES | GLIATECH INC (US) | 2002-09-18 | — | — | EP | claimed |
| EP-0214058-B1 | PHARMACEUTICAL COMPOSITION CONTAINING HISTAMINE DERIVATIVES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1992-05-06 | — | — | EP | claimed |
| EP-1313470-A4 | NOVEL ALICYCLIC IMIDAZOLES AS H 3 AGENTS | GLIATECH INC (US) | 2005-02-16 | — | — | EP | disclosed |
| US-6794405-B2 | Alicyclic imidazoles as H3 agents | MERCK & CO., INC. | 2004-09-21 | — | — | US | disclosed |
| US-20040029943-A1 | Novel alicylic imidazoles as H3 agents | MERCK SHARP & DOHME CORP. | 2004-02-12 | — | — | US | disclosed |
| EP-1313470-A1 | NOVEL ALICYCLIC IMIDAZOLES AS H 3 AGENTS | GLIATECH, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-0655914-B1 | Use of Histamine-2 agonists for treatment of sexual dysfunction | NAHOUM CESAR ROBERTO DIAS (BR) | 2003-02-26 | — | — | EP | disclosed |
| US-20020042400-A1 | Novel alicyclic imidazoles as H3 agents | GLIATECH, INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2002013821-A1 | NOVEL ALICYCLIC IMIDAZOLES AS H3 AGENTS | GLIATECH, INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| US-20010047100-A1 | Chiral imidazoyl intermediates for the synthesis of 2-(4-imidazoyl)-cyclopropyl derivatives | KJAERSGAARD HANS JOERGEN (DK) | 2001-11-29 | — | — | US | disclosed |
| WO-2001081317-A1 | CHIRAL IMIDAZOYL INTERMEDIATES FOR THE SYNTHESIS OF 2-(4-IMIDAZOYL)-CYCLOPROPYL DERIVATIVES | GLIATECH, INC. (US) | 2001-11-01 | — | — | WO | disclosed |
| US-5908853-A | THERAPY FOR SEXUAL DISORDERS | Nahoum, Cesar Roberto Dias (BR) | 1999-06-01 | — | — | US | disclosed |
| EP-0655914-A4 | NOVEL COMPOSITIONS. | NAHOUM CESAR ROBERTO DIAS (BR) | 1998-04-22 | — | — | EP | disclosed |
| EP-0482183-B1 | HISTAMINE H3-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION | INST NAT SANTE RECH MED (FR) | 1997-07-30 | — | — | EP | disclosed |
| US-5652258-A | HISTAMINE ANTAGONISTS | GLIATECH, INC. (US) | 1997-07-29 | — | — | US | disclosed |
| EP-0655914-A1 | NOVEL COMPOSITIONS | NAHOUM, Cesar Roberto Dias (BR) | 1995-06-07 | — | — | EP | disclosed |
| US-5342960-A | Azomethines agonist compounds of the histamine H3 receptor for therapeutic use, pharmaceutical compositions acting as agonists of the said receptor and preparation process | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1994-08-30 | — | — | US | disclosed |
| WO-1994004120-A2 | METHODS OF TREATING SEXUAL DYSFUNCTION IN ANIMALS WITH AND H AGONIST | NAHOUM CESAR ROBERTO DIAS (BR) | 1994-03-03 | — | — | WO | disclosed |
| WO-1991017146-A1 | NOVEL HISTAMINE H3-RECEPTOR AGONIST COMPOUNDS FOR THERAPEUTIC USE, PHARMACEUTICAL COMPOSITIONS ACTING AS AGONISTS OF SAID RECEPTOR AND METHOD OF PREPARATION | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1991-11-14 | — | — | WO | disclosed |
| US-4767778-A | HISTAMINE DERIVATIVES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1988-08-30 | — | — | US | disclosed |