Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136674 | 1.00 | ALOX15 (0.37) | ALOX15SMN1; SMN2LMNACACNA1HALDH1A1 | |
| SCHEMBL6136677 | 1.00 | ALOX15 (0.37) | ALOX15SMN1; SMN2LMNACACNA1HALDH1A1 | |
| Hydrochloric Acid SCHEMBL6136815 | 0.83 | ALOX15 (0.53) | ALOX15ADRB3ADRB1ADRB2 | |
| Hydrochloric Acid SCHEMBL6136807 | 0.83 | ALOX15 (0.53) | ALOX15ADRB3ADRB1ADRB2 | |
| Hydrochloric Acid SCHEMBL6136803 | 0.83 | ALOX15 (0.53) | ALOX15ADRB3ADRB1ADRB2 | |
| SCHEMBL6328477 | 0.80 | ADRB3 (0.50) | SMN1; SMN2ALDH1A1KDM4EADRB3RAB9A | |
| SCHEMBL6328475 | 0.80 | ADRB3 (0.50) | SMN1; SMN2ALDH1A1KDM4EADRB3RAB9A | |
| SCHEMBL4584814 | 0.79 | ADRB3 (0.40) | ALDH1A1PDE4AKDM4EADRB3MAPT | |
| SCHEMBL5689212 | 0.71 | CACNA1H (0.34) | SMN1; SMN2LMNACACNA1HALDH1A1PDE4A | |
| SCHEMBL5689222 | 0.71 | CACNA1H (0.34) | SMN1; SMN2LMNACACNA1HALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994105-B1 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | PFIZER PROD INC (US) | 2005-12-14 | — | — | EP | disclosed |
| US-6124457-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-09-26 | — | — | US | disclosed |
| US-6090942-A | Process and intermediates for a β3 -adrenergic receptor agonist | PFIZER INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0994105-A2 | 2-amino-pyridine intermediates for beta3-Adrenergic receptor agonists | Pfizer Products Inc. (US) | 2000-04-19 | — | — | EP | disclosed |