Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 2/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 12/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6136962 | 0.86 | CYSLTR1 (0.48) | CYSLTR2CYSLTR1 | |
| Acetic Acid SCHEMBL6136959 | 0.86 | CYSLTR1 (0.48) | CYSLTR2CYSLTR1 | |
| SCHEMBL6137019 | 0.72 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1 | |
| SCHEMBL6137141 | 0.72 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1 | |
| SCHEMBL10559803 | 0.70 | CYSLTR2 (0.53) | CTSDCYSLTR2CYSLTR1 | |
| SCHEMBL10775711 | 0.69 | CYSLTR2 (0.57) | CTSDCYSLTR2CYSLTR1 | |
| SCHEMBL10776074 | 0.68 | CYSLTR2 (0.56) | CTSDCYSLTR2CYSLTR1 | |
| SCHEMBL10772518 | 0.67 | GRM2 (0.56) | CYSLTR2CYSLTR1 | |
| SCHEMBL10556655 | 0.66 | CYSLTR2 (0.53) | CTSDCYSLTR2CYSLTR1 | |
| SCHEMBL7971466 | 0.66 | CTSD (0.65) | CTSDCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1011651-B1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1011651-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | Merck & Co., Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-1011651-A4 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6020382-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-5847008-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997027847-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | disclosed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | disclosed |