SCHEMBL6137167

SCHEMBL6137167

CCCCCCc1cc(C#N)ccc1N

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.51
HSD17B10 Q99714 1/20 0.51
CYP19A1 P11511 6/20 0.40
LIPG Q9Y5X9 1/20 0.40
DRD2 P14416 2/20 0.40
DRD3 P35462 2/20 0.40
MAPT P10636 3/20 0.39
HTT P42858 2/20 0.39
MEN1 O00255 1/20 0.39
TP53 P04637 1/20 0.39
CYP3A4 P08684 1/20 0.39
ALOX5 P09917 1/20 0.39
TYR P14679 1/20 0.39
ALOX15 P16050 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
TLR8 Q9NR97 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
ALDH1A1 P00352 3/20 0.37
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20526615 0.86 HRH4 (0.46) TSHRHSD17B10CYP19A1MAPTMEN1
SCHEMBL10882791 0.82 TSHR (0.53) TSHRHSD17B10CYP19A1LIPGDRD2
SCHEMBL15174598 0.82 TSHR (0.53) TSHRHSD17B10CYP19A1LIPGDRD2
SCHEMBL17672994 0.82 ALDH1A1 (0.34) TSHRHSD17B10MAPTCYP3A4ALDH1A1
SCHEMBL17629868 0.82 TLR7 (0.34) TSHRHSD17B10DRD2DRD3MAPT
SCHEMBL17679304 0.81 TSHR (0.51) TSHRHSD17B10CYP19A1LIPGDRD2
SCHEMBL19175675 0.80 TSHR (0.42) TSHRHSD17B10DRD2DRD3MAPT
SCHEMBL398911 0.79 ALDH1A1 (0.56) MAPTHRH4ALDH1A1POLBKDM4E
SCHEMBL15721486 0.79 TSHR (0.49) TSHRHSD17B10CYP19A1LIPGDRD2
SCHEMBL7879464 0.79 TSHR (0.49) TSHRHSD17B10LIPGDRD2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313560-A4 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION UNIV YALE (US) 2005-02-09 EP disclosed
EP-1313560-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2003-05-28 EP disclosed
WO-2002011883-A1 CATALYST FOR AROMATIC C-O, C-N, and C-C BOND FORMATION YALE UNIVERSITY (US) 2002-02-14 WO disclosed