Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 13/20 | 0.37 |
| ▸ | CA2 | P00918 | 13/20 | 0.37 |
| ▸ | CA12 | O43570 | 8/20 | 0.37 |
| ▸ | CA9 | Q16790 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.30 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.30 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.30 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137842 | 0.85 | SOS1 (0.37) | CA1CA2LMNASOS1 | |
| SCHEMBL6137899 | 0.78 | MAP2K1 (0.35) | CA1CA2CA9 | |
| SCHEMBL6138196 | 0.75 | CA1 (0.40) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6137945 | 0.73 | MAP2K1 (0.39) | CA1CA2CA9 | |
| SCHEMBL6137543 | 0.71 | IDO1 (0.33) | CA2 | |
| SCHEMBL6137971 | 0.67 | MEN1 (0.37) | — | |
| SCHEMBL6137709 | 0.65 | SOS1 (0.38) | CA1CA2LMNAP2RY2P2RY4 | |
| SCHEMBL6137930 | 0.65 | MGAM (0.34) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6138001 | 0.65 | CA1 (0.40) | CA1CA2CA12CA9LMNA | |
| SCHEMBL6137882 | 0.63 | LMNA (0.32) | CA1CA2CA12CA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144394-B1 | 1-HETEROCYCLE SUBSTITUTED DIARYLAMINES | WARNER LAMBERT CO (US) | 2005-08-24 | — | — | EP | disclosed |
| CN-1149204-C | 1-heterocyclic substituted diarylamines | ��ʲ | 2004-05-12 | — | — | CN | disclosed |
| US-6545030-B1 | Treating proliferative diseases, the sequelae of a stroke or heart failure, xenograft rejection, osteoarthritis, HIV, rheumatoid arthritis, cystic fibrosis, hepatomegaly, shock,cardiomegaly, Alzheimer's disease, diabetes | WARNER-LAMBERT COMPANY | 2003-04-08 | — | — | US | disclosed |
| US-20030004193-A1 | 1-Heterocycle substituted diarylamines | BARRETT STEPHEN DOUGLAS (US) | 2003-01-02 | — | — | US | disclosed |
| CN-1358095-A | Methods of treating chronic pain using MEK inhibitors | WARNER LAMBERT CO (US) | 2002-07-10 | — | — | CN | disclosed |
| EP-1202732-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-05-08 | — | — | EP | disclosed |
| CN-1334807-A | 1-heterocycle substd. diarylamines | WARNER LAMBERT CO (US) | 2002-02-06 | — | — | CN | disclosed |
| EP-1144394-A1 | 1-HETEROCYCLE SUBSTITUTED DIARYLAMINES | WARNER-LAMBERT COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2001005391-A2 | METHOD FOR TREATING CHRONIC PAIN USING MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-01-25 | — | — | WO | disclosed |
| WO-2000042029-A1 | 1-HETEROCYCLE SUBSTITUTED DIARYLAMINES | WARNER-LAMBERT COMPANY (US) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004193-A1 | 1-Heterocycle substituted diarylamines | IDH3A, CCNA1, HCCS | CA1 842/4885CA2 3273/4885CA12 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.