Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 5/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 5/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 5/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 5/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 5/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.42 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651847 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL43515 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL503347 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2652715 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL123134 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5980862 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL5605868 | 0.91 | GRIN2D (0.49) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL971795 | 0.89 | GRIN2D (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Water SCHEMBL2651079 | 0.89 | GRIN2D (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Hydrochloric Acid SCHEMBL971796 | 0.89 | GRIN2D (0.47) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368378-A4 | CONSTITUTIVELY DESENSITIZED G PROTEIN-COUPLED RECEPTORS | UNIV DUKE (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1368378-A2 | CONSTITUTIVELY DESENSITIZED G PROTEIN-COUPLED RECEPTORS | Duke University (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002059267-A2 | CONSTITUTIVELY DESENSITIZED G PROTEIN-COUPLED RECEPTORS | DUKE UNIVERSITY (US) | 2002-08-01 | — | — | WO | disclosed |
| US-5631222-A | TREATMENT OF ASTHMA, ANGINA PECTORIS, CARDIOVASCULAR AND BRAIN DISORDERS; HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-05-20 | — | — | US | disclosed |