Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6138408 | 0.91 | CHRNB2 (0.41) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| Fumaric Acid SCHEMBL6138400 | 0.91 | CHRNB2 (0.41) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| SCHEMBL6138367 | 0.90 | CHRNB2 (0.46) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| Fumaric Acid SCHEMBL6290169 | 0.81 | CHRNB2 (0.43) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| Fumaric Acid SCHEMBL6290171 | 0.81 | CHRNB2 (0.43) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| SCHEMBL6137965 | 0.79 | CHRNB2 (0.46) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL12172818 | 0.73 | EPHX1 (0.71) | EPHX1CHRNB2CHRNA4MAPK1CHRM2 | |
| Fumaric Acid SCHEMBL6138515 | 0.72 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| Fumaric Acid SCHEMBL6138512 | 0.72 | CHRNB2 (0.39) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL6138405 | 0.72 | ATM (0.35) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | claimed |
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | disclosed |
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |