Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6378829 | 0.90 | ALDH1A1 (0.57) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL9681942 | 0.77 | ALDH1A1 (0.54) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL6377108 | 0.77 | CYP1A2 (0.50) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL7768508 | 0.77 | CYP1A2 (0.50) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL7768825 | 0.74 | CYP1A2 (0.37) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL2612028 | 0.73 | — | — | |
| SCHEMBL4570512 | 0.71 | CYP1A2 (0.45) | CYP1A2USP2ALDH1A1LMNATSHR | |
| SCHEMBL1659398 | 0.70 | — | — | |
| SCHEMBL6382551 | 0.70 | ALDH1A1 (0.49) | CYP1A2USP2ALDH1A1LMNATSHR | |
| Dimethylformamide SCHEMBL3227610 | 0.70 | CYP1A2 (0.36) | CYP1A2USP2ALDH1A1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |