Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758478 | 0.85 | LMNA (0.61) | LMNAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8637764 | 0.84 | LMNA (0.60) | LMNAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7758537 | 0.82 | MEN1 (0.57) | LMNAKDM4EALDH1A1TSHRHTT | |
| SCHEMBL8625965 | 0.81 | MEN1 (0.61) | LMNAKDM4EALDH1A1HTTMEN1 | |
| Hydrochloric Acid SCHEMBL8639764 | 0.81 | MEN1 (0.56) | LMNAKDM4EALDH1A1TSHRHTT | |
| Hydrochloric Acid SCHEMBL6774991 | 0.81 | LMNA (0.55) | LMNAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7756367 | 0.81 | MEN1 (0.55) | LMNASMN1; SMN2KDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL6779307 | 0.80 | LMNA (0.57) | LMNAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL8640761 | 0.80 | MEN1 (0.60) | LMNAKDM4EALDH1A1HTTMEN1 | |
| Hydrochloric Acid SCHEMBL8634672 | 0.80 | MEN1 (0.54) | LMNASMN1; SMN2KDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1277746-B1 | N-benzylpiperazine derivatives, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-05-11 | — | — | EP | disclosed |
| EP-1277746-A2 | N-benzylpiperazine derivatives, process for their preparation and pharmaceutical compositions thereof | Les Laboratoires Servier (FR) | 2003-01-22 | — | — | EP | disclosed |