Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5631721 | 1.00 | SIRT6 (0.46) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL10573750 | 0.82 | SIRT6 (0.49) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL10573753 | 0.82 | SIRT6 (0.49) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL5630426 | 0.80 | MAPT (0.36) | POLBMAPTALDH1A1MAPK1GAA | |
| SCHEMBL5698195 | 0.80 | MAPT (0.36) | POLBMAPTALDH1A1MAPK1GAA | |
| SCHEMBL4709358 | 0.76 | SIRT6 (0.56) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL7406656 | 0.74 | SIRT6 (0.53) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL6203168 | 0.74 | MAPT (0.34) | POLBMAPTALDH1A1GAAPKM | |
| SCHEMBL10898746 | 0.73 | MAPT (0.46) | SIRT6ADRB1POLBMAPTALDH1A1 | |
| SCHEMBL5310568 | 0.68 | SIRT6 (0.53) | SIRT6ADRB1POLBMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183277-B2 | Alpha-((aryl or heteroaryl)ureido or carbamoyloxy)-N-heteroaryl amides; blood-coagulation factor Xa and VIIa inhibitors; synergistic mixtures with other antitumor agents or anticoagulants | MERCK PATENT GMBH (DE) | 2007-02-27 | — | — | US | disclosed |
| EP-1499591-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GmbH (DE) | 2005-01-26 | — | — | EP | disclosed |
| WO-2003093235-A1 | CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2003-11-13 | — | — | WO | disclosed |