Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.49 |
| ▸ | PLG | P00747 | 8/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 8/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 8/20 | 0.41 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSS | P25774 | 4/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PTPRA | P18433 | 2/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1732436 | 0.93 | PTPN1 (0.53) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL1732438 | 0.93 | PTPN1 (0.53) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6141344 | 0.92 | PTPN1 (0.48) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL1732320 | 0.91 | PTPN1 (0.47) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6151250 | 0.90 | PTPN1 (0.44) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6141617 | 0.89 | PTPN1 (0.49) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL1731127 | 0.89 | PTPN1 (0.41) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL1731123 | 0.89 | PTPN1 (0.41) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6282167 | 0.87 | PTPN1 (0.62) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL1732761 | 0.87 | PTPN1 (0.54) | PTPN1PLGPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492780-A1 | 5-SUBSTITUTED 1,1-DIOXO-[1,2,5]THIAZOLIDINE-3-ONE DERIVATIVES AS PTPASE 1B INHIBITORS | Novartis AG (CH) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082841-A1 | 5-SUBSTITUTED 1,1-DIOXO-`1,2,5!THIAZOLIDINE-3-ONE DERIVATIVES AS PTPASE 1B INHIBITORS | NOVARTIS AG (CH) | 2003-10-09 | — | — | WO | disclosed |