Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.62 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.44 |
| ▸ | CHRNG | P07510 | 4/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.44 |
| ▸ | CHRND | Q07001 | 4/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.43 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1732762 | 0.94 | PTPN1 (0.54) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL1732761 | 0.94 | PTPN1 (0.54) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL6141344 | 0.90 | PTPN1 (0.48) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL1732436 | 0.90 | PTPN1 (0.53) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL1732438 | 0.90 | PTPN1 (0.53) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL6141529 | 0.87 | PTPN1 (0.49) | PTPN1KLKB1PLGPRSS1PRSS2 | |
| SCHEMBL6141374 | 0.85 | LCK (0.47) | PTPN1CTSL | |
| SCHEMBL1731192 | 0.85 | PTPN1 (0.47) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL6925818 | 0.85 | PTPN1 (0.47) | PTPN1PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL5893060 | 0.85 | PTPN1 (0.70) | PTPN1CHRNA1CHRNGCHRNB1CHRND |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005035551-A2 | INHIBITORS OF PROTEINS THAT BIND PHOSPHORYLATED MOLECULES | INCYTE CORPORATION (US) | 2005-04-21 | — | — | WO | disclosed |