SCHEMBL6142005

SCHEMBL6142005

C=CCCc1ccc(C#Cc2ccc(-c3ccc(C#Cc4ccc(C#N)cc4)cc3)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.49
HSD17B10 Q99714 1/20 0.49
MMP12 P39900 1/20 0.42
MMP13 P45452 1/20 0.42
KCNJ1 P48048 1/20 0.41
KCNH2 Q12809 1/20 0.41
LOXL2 Q9Y4K0 2/20 0.40
CYP2A6 P11509 1/20 0.40
MMP3 P08254 1/20 0.40
HRH3 Q9Y5N1 3/20 0.39
FFAR1 O14842 1/20 0.39
CYP19A1 P11511 3/20 0.38
KIF11 P52732 2/20 0.37
LSS P48449 1/20 0.36
CYP1A2 P05177 1/20 0.36
POLB P06746 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7851897 1.00 TSHR (0.49) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL9457628 0.95 TSHR (0.53) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL7851913 0.95 KCNJ1 (0.44) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL19599400 0.90 TSHR (0.49) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL2968409 0.89 KCNJ1 (0.48) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL19599410 0.89 TSHR (0.64) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL29637029 0.86 FFAR1 (0.41) FFAR1
SCHEMBL10341661 0.85 TSHR (0.58) TSHRHSD17B10MMP12MMP13KCNJ1
SCHEMBL7858870 0.83 TSHR (0.41) TSHRHSD17B10HRH3FFAR1
SCHEMBL6142146 0.83 FFAR1 (0.49) TSHRHSD17B10KCNH2CYP2A6FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0930286-B1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORP (JP) 2005-01-12 EP disclosed
US-6333080-B1 HIGH ANISOTROPY, HIGH ELASTIC CONSTANT RATIO, EXCELLENT COMPARABILITY WITH OTHER LIQUID-CRYSTAL COMPOUNDS, AND LOW VISCOSITY AND ARE CHEMICALLY AND PHYSICALLY STABLE CHISSO CORPORATION (JP) 2001-12-25 US disclosed
EP-0930286-A1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORPORATION (JP) 1999-07-21 EP disclosed