Sugi Predict

Sugi Predict / Compounds / SCHEMBL614204

SCHEMBL614204

SCHEMBL614204

Cc1c2ccn(C)c(=O)c2c(C)c2c1[nH]c1ccc(O)cc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KIT P10721 4/20 0.51
▸ PDGFRA P16234 2/20 0.51
▸ FGFR3 P22607 2/20 0.51
▸ CHEK1 O14757 5/20 0.49
▸ WEE1 P30291 3/20 0.49
▸ ROCK2 O75116 4/20 0.46
▸ CDK5 Q00535 3/20 0.43
▸ CDK5R1 Q15078 3/20 0.43
▸ DYRK1A Q13627 2/20 0.43
▸ CYP1A2 P05177 2/20 0.43
▸ CYP2D6 P10635 2/20 0.43
▸ GSK3A P49840 2/20 0.42
▸ GSK3B P49841 2/20 0.42
▸ TOP1 P11387 1/20 0.42
▸ SRC P12931 1/20 0.41
▸ HPGD P15428 1/20 0.40
▸ ALOX15 P16050 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ HIF1A Q16665 1/20 0.40
▸ CDK4 P11802 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL614782 0.83 KDM4E (0.53) KITROCK2DYRK1AGSK3AGSK3B
SCHEMBL31061690 0.77 LIMK1 (0.61) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL614767 0.77 LIMK1 (0.61) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL16433310 0.69 KIT (0.56) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL2547904 0.69 GAA (0.43) CHEK1WEE1ROCK2CDK5CDK5R1
SCHEMBL9623245 0.68 WEE1 (0.50) KITPDGFRAFGFR3CHEK1WEE1
Hydrochloric Acid SCHEMBL9623367 0.68 WEE1 (0.49) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL31060598 0.68 KIT (1.00) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL564035 0.68 KIT (1.00) KITPDGFRAFGFR3CHEK1WEE1
SCHEMBL23223691 0.67 KIT (0.47) KITPDGFRAFGFR3CHEK1WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8604048-B2 Pyridocarbazole type compounds and applications thereof CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2013-12-10 — — US disclosed
US-20120041017-A1 PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-02-16 — — US disclosed
US-20120041017-A1 PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-02-16 — — US disclosed
US-20120041017-A1 PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2012-02-16 — — US disclosed
WO-2010095042-A2 PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF CENTRE NATONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2010-08-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120041017-A1 PYRIDOCARBAZOLE TYPE COMPOUNDS AND APPLICATIONS THEREOF NLN, OPA1, PYCR1 KIT 4688/4885PDGFRA 3344/4885FGFR3 3741/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.