SCHEMBL6142115

SCHEMBL6142115

C=CCC[C@H]1CC[C@H](CC[C@H]2CC[C@H](c3ccc(C#Cc4ccc(Cl)cc4)cc3)CC2)CC1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 3/20 0.37
DRD2 P14416 2/20 0.35
IDO1 P14902 1/20 0.34
CYP2C9 P11712 3/20 0.33
HTR3A P46098 1/20 0.33
ESR1 P03372 1/20 0.33
CYP3A4 P08684 1/20 0.33
LSS P48449 1/20 0.32
GRM2 Q14416 1/20 0.32
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
MAPT P10636 3/20 0.32
LMNA P02545 2/20 0.32
ALDH1A1 P00352 1/20 0.32
SLC2A1 P11166 1/20 0.32
MAPK1 P28482 1/20 0.32
HTR1A P08908 1/20 0.31
DRD1 P21728 1/20 0.31
DRD5 P21918 1/20 0.31
HTR2A P28223 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6142127 0.99 ESR2 (0.38) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL6142186 0.95 ESR2 (0.35) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL6142259 0.95 DGAT1 (0.36) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL9250432 0.92 ESR2 (0.42) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL9250423 0.92 ESR2 (0.42) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL9250428 0.92 ESR2 (0.42) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL9136639 0.87 ESR2 (0.40) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL8034940 0.87 ESR2 (0.40) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL8034935 0.87 ESR2 (0.40) ESR2DRD2IDO1CYP2C9HTR3A
SCHEMBL8034938 0.87 ESR2 (0.40) ESR2DRD2IDO1CYP2C9HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0930286-B1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORP (JP) 2005-01-12 EP disclosed
US-6333080-B1 HIGH ANISOTROPY, HIGH ELASTIC CONSTANT RATIO, EXCELLENT COMPARABILITY WITH OTHER LIQUID-CRYSTAL COMPOUNDS, AND LOW VISCOSITY AND ARE CHEMICALLY AND PHYSICALLY STABLE CHISSO CORPORATION (JP) 2001-12-25 US disclosed
EP-0930286-A1 LIQUID-CRYSTAL ALKENYLTOLAN DERIVATIVE, LIQUID-CRYSTAL COMPOSITION, AND LIQUID-CRYSTAL DISPLAY ELEMENT CHISSO CORPORATION (JP) 1999-07-21 EP disclosed