Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.76 |
| ▸ | ESR2 | Q92731 | 19/20 | 0.76 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.64 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141708 | 0.93 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141716 | 0.91 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8674595 | 0.90 | ESR1 (0.83) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL5419626 | 0.89 | ESR1 (0.72) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8598353 | 0.88 | ESR1 (0.89) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8598366 | 0.88 | ESR1 (0.89) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141703 | 0.88 | ESR1 (0.80) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8600306 | 0.87 | ESR1 (0.88) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6142024 | 0.87 | ESR1 (0.77) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141664 | 0.87 | ESR1 (0.86) | ESR1ESR2ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493741-A2 | Benzo[b]thiophene compounds, intermediates, processes, compositions and methods | Eli Lilly & Company (US) | 2005-01-05 | — | — | EP | disclosed |
| EP-0826683-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2004-10-06 | — | — | EP | disclosed |
| US-5998442-A | ANTICHOLESTEROL AGENTS | ELI LILLY AND COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0826683-A1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |