Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.83 |
| ▸ | ESR2 | Q92731 | 19/20 | 0.83 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.62 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675998 | 0.91 | ESR1 (1.00) | ESR1ESR2 | |
| SCHEMBL6142122 | 0.90 | ESR1 (0.76) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141716 | 0.90 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL5419626 | 0.87 | ESR1 (0.72) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8674307 | 0.87 | ESR1 (0.83) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8598366 | 0.87 | ESR1 (0.89) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL8598353 | 0.87 | ESR1 (0.89) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141708 | 0.86 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141743 | 0.86 | ESR1 (0.84) | ESR1ESR2ENPP3ENPP1 | |
| SCHEMBL6141703 | 0.86 | ESR1 (0.80) | ESR1ESR2ENPP3ENPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5728724-A | TREATMENT OF POSTMENOPAUSE SYNDROME, OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN DEPENDENT CANCER | ELI LILLY AND COMPANY (US) | 1998-03-17 | — | — | US | disclosed |
| WO-1997006796-A1 | BENZOTHIOPHENE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1997-02-27 | — | — | WO | disclosed |
| EP-0759434-A1 | Benzothiophene compounds | ELI LILLY AND COMPANY (US) | 1997-02-26 | — | — | EP | disclosed |