Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 5/20 | 0.35 |
| ▸ | MAOB | P27338 | 5/20 | 0.35 |
| ▸ | KDM1A | O60341 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739415 | 1.00 | GBA1 (0.46) | GBA1PRCPMEN1KMT2APARP3 | |
| SCHEMBL24365777 | 0.82 | GBA1 (0.44) | GBA1PRCPMEN1KMT2APARP3 | |
| SCHEMBL29081640 | 0.82 | GBA1 (0.44) | GBA1PRCPMEN1KMT2APARP3 | |
| SCHEMBL24367023 | 0.82 | GBA1 (0.44) | GBA1PRCPMEN1KMT2APARP3 | |
| SCHEMBL8565971 | 0.80 | SCN10A (0.38) | PRCPSCN10ACYP2C19CYP1A2HSD17B10 | |
| SCHEMBL4685465 | 0.80 | CDC7 (0.40) | SCN10AMAOBKDM1ACYP2C19CYP2D6 | |
| SCHEMBL27603362 | 0.80 | SCN10A (0.35) | MEN1KMT2ASCN10ACYP3A4HSD17B10 | |
| SCHEMBL4195137 | 0.80 | SLC18A3 (0.39) | GBA1PRCPMEN1KMT2ACYP2C19 | |
| SCHEMBL24365527 | 0.80 | SLC18A3 (0.39) | GBA1PRCPMEN1KMT2ACYP2C19 | |
| SCHEMBL9158920 | 0.80 | SLC18A3 (0.39) | GBA1PRCPMEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515949-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-1515949-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1515724-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1515724-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| EP-1515949-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004087050-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2004-10-14 | — | — | WO | disclosed |
| WO-2003106417-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | disclosed |
| WO-2003105855-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-12-24 | — | — | WO | disclosed |