Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | VHL | P40337 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035650 | 0.85 | PLA2G4B (0.39) | PPARAPPARGPPARDPLA2G4BNR1H2 | |
| SCHEMBL6143442 | 0.84 | PPARA (0.43) | PPARAPPARGPPARDPTGDR2CYP2C9 | |
| SCHEMBL6035564 | 0.84 | PLA2G4B (0.42) | PPARAPPARGPPARDPLA2G4BCYP2C9 | |
| SCHEMBL5904704 | 0.84 | NR1H3 (0.44) | PPARAPPARGPPARDPTGDR2PLA2G4B | |
| SCHEMBL5904705 | 0.81 | PTGDR2 (0.48) | PPARAPPARGPPARDPTGDR2CYP2C9 | |
| SCHEMBL6035936 | 0.80 | PPARD (0.44) | PPARAPPARGPPARDPTGDR2NR1H2 | |
| SCHEMBL5904556 | 0.80 | FFAR2 (0.40) | PPARAPPARGPPARDPTGDR2CYP2C9 | |
| SCHEMBL5904716 | 0.80 | PPARA (0.47) | PPARAPPARGPPARDPTGDR2CYP2C9 | |
| SCHEMBL6036002 | 0.80 | NR1H2 (0.45) | PPARAPPARGPPARDPTGDR2NR1H2 | |
| SCHEMBL6035924 | 0.78 | SMN1; SMN2 (0.39) | PPARAPPARGPPARDPLA2G4BNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585733-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | claimed |
| WO-2004063166-A1 | HETEROCYCLIC PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | claimed |