Vinblastine

Vinblastine

SCHEMBL6146

CC[C@]1(O)C[C@H]2CN(CCc3c([nH]c4ccccc34)[C@@](C(=O)OC)(c3cc4c(cc3OC)N(C)[C@H]3[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]5(CC)C=CCN6CC[C@]43[C@@H]65)C2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8

The experimentally established mechanism targets of Vinblastine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 6/20 1.00
TUBB known ✓ P07437 6/20 1.00
TUBA3C known ✓ P0DPH7 6/20 1.00
TUBA1B known ✓ P68363 6/20 1.00
TUBA4A known ✓ P68366 6/20 1.00
TUBB4B known ✓ P68371 6/20 1.00
TUBB3 known ✓ Q13509 6/20 1.00
TUBB2A known ✓ Q13885 6/20 1.00
TUBB8 known ✓ Q3ZCM7 6/20 1.00
TUBA3E known ✓ Q6PEY2 6/20 1.00
TUBA1A known ✓ Q71U36 6/20 1.00
TUBA1C known ✓ Q9BQE3 6/20 1.00
TUBB6 known ✓ Q9BUF5 6/20 1.00
TUBB2B known ✓ Q9BVA1 6/20 1.00
TUBB1 known ✓ Q9H4B7 6/20 1.00
MAPT P10636 8/20 1.00
MEN1 O00255 7/20 1.00
KMT2A Q03164 7/20 1.00
LMNA P02545 6/20 1.00
CYP3A4 P08684 6/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vinblastine SCHEMBL3628 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL18593671 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL3629 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL14107274 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL17813675 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL153952 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL19884331 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL22450052 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL22022258 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB
Vinblastine SCHEMBL15745871 1.00 MAPT (1.00) MAPTMEN1KMT2ATUBB4ATUBB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2376 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720329-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SensID GmbH (DE) 2026-04-08 EP claimed
US-12370175-B2 Glucocorticoid receptor modulators to treat pancreatic cancer CORCEPT THERAPEUTICS, INC. (US) 2025-07-29 US claimed
US-12257251-B2 Use of FAK inhibitor in preparation of drug for treating tumors having NRAS mutation INXMED (NANJING) CO., LTD. (CN) 2025-03-25 US claimed
WO-2024246014-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SENSID GMBH (DE) 2024-12-05 WO claimed
EP-4467659-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS WITH A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSIS SensID GmbH (DE) 2024-11-27 EP claimed
US-20230364088-A1 USE OF FAK INHIBITOR IN PREPARATION OF DRUG FOR TREATING TUMORS HAVING NRAS MUTATION INXMED (BEIJING) CO., LTD. (CN) 2023-11-16 US claimed
US-20230285361-A1 GLUCOCORTICOID RECEPTOR MODULATORS TO TREAT PANCREATIC CANCER CORCEPT THERAPEUTICS, INC. (US) 2023-09-14 US claimed
US-20230145356-A1 USE OF FAK INHIBITOR IN PREPARATION OF DRUG FOR TREATING TUMORS HAVING NRAS MUTATION INXMED (NANJING) CO., LTD. (CN) 2023-05-11 US claimed
EP-4062914-A1 USE OF FAK INHIBITOR IN PREPARATION OF DRUG FOR TREATING TUMORS HAVING NRAS MUTATION Inxmed (Nanjing) Co., Ltd. (CN) 2022-09-28 EP claimed
CN-111411077-B Application of small molecular substance in preparation of reagent for maintaining tendon stem cell phenotype in vitro 浙江大学 2022-02-25 CN claimed
CN-111411077-A Application of small molecular substance in preparation of reagent for maintaining tendon stem cell phenotype in vitro 浙江大学 2020-07-14 CN claimed
US-20200165608-A1 INHIBITION OF VASCULAR ENDOTHELIAL CELL-MEDIATED PHAGOCYTIC PROCESSES FOR TREATMENT OF DEMYELINATING CONDITIONS NATIONAL SCIENCE FOUNDATION 2020-05-28 US claimed
US-20190015423-A1 REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2019-01-17 US claimed
WO-2013067543-A1 METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY FOLLEA INTERNATIONAL LTD. (CN) 2013-05-10 WO claimed
US-20130115180-A1 Methods And Compositions For Administering A Specific Wavelength Phototherapy APPLIED BIOLOGY, INC. 2013-05-09 US claimed
US-6589941-B1 Preventing or reducing formation of resistance in cytostatic treatment comprising combining BVDU, a salt thereof or BVDU in protected form or in prodrug form with at least one cytostatic agent in order to prevent or reduce the formation RESPROTECT GMBH (DE) 2003-07-08 US claimed
US-6353124-B1 NONSTEROIDAL ANTIINFLAMMATORY AGENTS (ASPIRIN, INDOMETHACIN, OR IBUPROFEN) LINKED BY TRIS AMINE OR ETHANOLAMINE DERIVATIVE TO THE ACYL GROUPS OF FATTY ACIDS; IMPROVED TRANSDERMAL DELIVERY COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2002-03-05 US claimed
US-6303621-B1 ADMINISTERING DIIODO THYRONINE ANALOGUE HAVING NO SIGNIFICANT HORMONAL ACTIVITY AND A VINCA ALKALOID SELECTED FROM LEUROSINE, VINCALEUKOBLASTINE, VINBLASTINE, LEUROFORMINE, LEUROSIDINE, LEUROCRISTINE, VINCRISTINE, DEOXY VINBLASTINE OCTAMER, INC. 2001-10-16 US claimed
EP-0014053-B1 SYNTHESIS OF VINDESINE; VINCALEUKOBLASTINE COMPOUNDS ELI LILLY AND COMPANY (US) 1983-12-14 EP claimed
EP-0014053-A1 Synthesis of vindesine; vincaleukoblastine compounds ELI LILLY AND COMPANY (US) 1980-08-06 EP claimed