Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 15/20 | 0.54 |
| ▸ | RARB | P10826 | 14/20 | 0.54 |
| ▸ | RARA | P10276 | 13/20 | 0.54 |
| ▸ | RXRA | P19793 | 8/20 | 0.45 |
| ▸ | RXRB | P28702 | 3/20 | 0.45 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6147382 | 1.00 | RARG (0.54) | RARGRARBRARARXRARXRB | |
| SCHEMBL6144234 | 0.94 | RARG (0.53) | RARGRARBRARARXRARXRB | |
| SCHEMBL6144238 | 0.94 | RARG (0.53) | RARGRARBRARARXRARXRB | |
| SCHEMBL6146577 | 0.92 | RARG (0.51) | RARGRARBRARARXRARXRB | |
| SCHEMBL6146571 | 0.92 | RARG (0.51) | RARGRARBRARARXRARXRB | |
| SCHEMBL6146872 | 0.89 | RARG (0.55) | RARGRARBRARARXRARXRB | |
| SCHEMBL6146880 | 0.89 | RARG (0.55) | RARGRARBRARARXRARXRB | |
| SCHEMBL6147075 | 0.88 | RARB (0.71) | RARGRARBRARARXRARXRB | |
| SCHEMBL6147082 | 0.88 | RARB (0.71) | RARGRARBRARARXRARXRB | |
| SCHEMBL6146419 | 0.86 | RARG (0.53) | RARGRARBRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280757-B1 | NEW GAMMA SELECTIVE RETINOIDS | HOFFMANN LA ROCHE (CH) | 2005-08-17 | — | — | EP | disclosed |
| US-6603012-B2 | RAR selective retinoid agonists | HOFFMANN-LA ROCHE INC. | 2003-08-05 | — | — | US | disclosed |
| US-20020026060-A1 | RAR selective retinoid agonists | F.HOFFMANN-LA ROCHE AG (CH) | 2002-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020026060-A1 | RAR selective retinoid agonists | RARA, RARG, RARB | RARG 2/4885RARB 3/4885RARA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.