Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 10/20 | 0.58 |
| ▸ | ESR1 | P03372 | 7/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6150771 | 0.80 | ESR2 (0.55) | ESR2ESR1MEN1GLAKMT2A | |
| SCHEMBL6150425 | 0.78 | ESR2 (0.56) | ESR2ESR1 | |
| SCHEMBL6151832 | 0.74 | ESR2 (0.53) | ESR2ESR1MEN1GLAKMT2A | |
| SCHEMBL6150789 | 0.73 | ESR2 (0.52) | ESR2ESR1MEN1GLAKMT2A | |
| SCHEMBL6151419 | 0.70 | ESR2 (0.56) | ESR2ESR1 | |
| SCHEMBL5051071 | 0.67 | OPRM1 (0.46) | ESR2ESR1OPRM1OPRD1OPRK1 | |
| SCHEMBL4858848 | 0.67 | ESR2 (0.80) | ESR2ESR1 | |
| SCHEMBL4858739 | 0.64 | ESR2 (0.83) | ESR2ESR1 | |
| SCHEMBL3959283 | 0.64 | ESR2 (0.51) | ESR2ESR1KDM4EALDH1A1MAPT | |
| SCHEMBL14243200 | 0.64 | MEN1 (0.45) | ESR2ESR1MEN1GLAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551820-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026887-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-04-01 | — | — | WO | disclosed |