Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | HRH2 | P25021 | 3/20 | 0.42 |
| ▸ | HRH1 | P35367 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6148402 | 0.88 | KCNH2 (0.51) | KCNA5MEN1KCNH2 | |
| SCHEMBL6146890 | 0.85 | CCR3 (0.37) | DRD3HRH2HRH1HRH3MEN1 | |
| SCHEMBL6150676 | 0.84 | KCNA5 (0.44) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL2967914 | 0.83 | DRD3 (0.57) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL2968137 | 0.80 | HRH1 (0.54) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL6095366 | 0.78 | DRD3 (0.60) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL2968099 | 0.76 | KCNA5 (0.54) | KCNA5HRH2HRH1HRH3MEN1 | |
| SCHEMBL6096247 | 0.75 | HRH1 (0.57) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL6992978 | 0.74 | DRD3 (0.58) | KCNA5DRD3HRH2HRH1HRH3 | |
| SCHEMBL6148397 | 0.74 | KCNH2 (0.53) | MEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235831-B1 | NEW OXABISPIDINE COMPOUNDS USEFUL IN THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2005-03-30 | — | — | EP | claimed |