Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA4 | P22748 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6184463 | 0.79 | PKM (0.54) | CA1CA2CA4CA9SLC6A2 | |
| Hydrochloric Acid SCHEMBL31302142 | 0.74 | SLC6A2 (0.56) | CA1CA2CA4CA9SLC6A2 | |
| Hydrochloric Acid SCHEMBL31302259 | 0.74 | SLC6A2 (0.56) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL3505492 | 0.72 | SLC6A2 (0.53) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL3505495 | 0.72 | SLC6A2 (0.53) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL3494370 | 0.71 | SLC6A2 (0.47) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL17962966 | 0.70 | COMT (0.74) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL3507388 | 0.70 | SLC6A2 (0.51) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL3507392 | 0.70 | SLC6A2 (0.51) | CA1CA2CA4CA9SLC6A2 | |
| SCHEMBL16430559 | 0.70 | ALOX5AP (0.48) | CA1CA2CA4CA9SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |