Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 19/20 | 0.58 |
| ▸ | ESR1 | P03372 | 15/20 | 0.58 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4854661 | 0.90 | ESR2 (0.55) | ESR2ESR1 | |
| SCHEMBL4857333 | 0.89 | ESR2 (0.62) | ESR2ESR1 | |
| SCHEMBL4860203 | 0.82 | ESR2 (0.61) | ESR2ESR1 | |
| SCHEMBL2422946 | 0.81 | ESR2 (0.73) | ESR2ESR1 | |
| SCHEMBL4861008 | 0.80 | ESR2 (0.56) | ESR2ESR1 | |
| SCHEMBL4853566 | 0.80 | ESR2 (0.57) | ESR2ESR1 | |
| SCHEMBL4859486 | 0.79 | ESR2 (0.60) | ESR2ESR1 | |
| SCHEMBL4852297 | 0.78 | ESR2 (0.59) | ESR2ESR1 | |
| SCHEMBL6150367 | 0.78 | ESR2 (0.39) | ESR2ESR1THRATHRB | |
| SCHEMBL6151086 | 0.78 | ESR2 (0.39) | ESR2ESR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551820-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026887-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-04-01 | — | — | WO | disclosed |