Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 6/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6151086 | 0.90 | ESR2 (0.39) | ESR2ESR1THRATHRBMEN1 | |
| SCHEMBL4854661 | 0.80 | ESR2 (0.55) | ESR2ESR1MEN1NPC1ALDH1A1 | |
| SCHEMBL4857357 | 0.80 | ESR1 (0.37) | ESR2ESR1THRATHRBMEN1 | |
| SCHEMBL6151438 | 0.78 | ESR2 (0.58) | ESR2ESR1THRATHRB | |
| SCHEMBL4914987 | 0.71 | THRA (0.37) | ESR2ESR1THRATHRBMEN1 | |
| SCHEMBL6151419 | 0.70 | ESR2 (0.56) | ESR2ESR1 | |
| SCHEMBL4858831 | 0.69 | THRA (0.58) | THRATHRBMEN1NPC1ALDH1A1 | |
| SCHEMBL6150947 | 0.69 | ESR2 (0.38) | ESR2ESR1 | |
| SCHEMBL4859486 | 0.69 | ESR2 (0.60) | ESR2ESR1METAP1 | |
| SCHEMBL2419794 | 0.68 | ESR2 (0.45) | ESR2ESR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551820-A2 | ESTROGEN RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004026887-A2 | ESTROGEN RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2004-04-01 | — | — | WO | disclosed |